joovv: Near infrared Light Therapy

Near Infrared Light Therapy, also known as photobiomodulation or low-level light therapy (LLLT), is well researched as a powerful recovery modality, with documented benefits for skin such as smooths overall skin tone, builds collagen, reducing wrinkles, including crow’s feet, under eye wrinkles, forehead wrinkles & laugh lines, speeds the healing of blemishes, like acne and rosacea, repairs sun damage, reduces redness, flushing, and broken capillaries, fades scars and stretch marks, brings more moisture to your skin, prevents hair loss & stimulates regrowth.  IR also speeds the healing of wounds and injuries to the body speeds wound healing in even non-healing wounds improves or restores range of motion reduces inflammation and pain.   Perfect post workout treatment.s.


Numerous studies have proven that light therapy—otherwise known as photobiomodulation—provides great benefits when a device combines the right wavelength of light with the right amount of power. Some of those benefits include:

  • Improved skin tone and complexion[1]
  • Enhanced muscle recovery[2]
  • Reduced acne, rosacea, and eczema[1]
  • Improved appearance of wrinkles, fine lines, scars, and stretch marks[1]
  • Enhanced circulation[3]
  • Quicker healing of wounds and injuries[3]
  • Reduced pain and inflammation[4]

Impressive list, right? But how does red and near infrared light therapy actually produce these types of results? What’s going on in our bodies that allows for this type of healing power?

You’re not alone if you’re asking these types of questions. I studied biology and chemistry as part of my undergraduate education, and when I started exploring the world of photobiomodulation, I asked myself the same things.

If you’ve done some research regarding the benefits of light therapy, you’ll often see the following as the rationale for its anti-aging properties:

  • Increased circulation, via the formation of new capillaries, is responsible for some benefits. Or, in other words, more blood and oxygen helps deliver proper nutrients to damaged areas in the body.[3]
  • Enhanced activity within your lymph system leads to a reduction in swelling and inflammation.[5]
  • Increased collagen production, which directly relates to the elasticity, firmness, and fullness of your skin.[5]

This is great information—and it makes sense. But unfortunately, most articles stop there. So, in this post, we’ll try to go a step further to answer this key question: How does red light therapy actually work at a cellular level?

Let’s Start With How Our Cells are Supposed to Function

All living things need to make a certain kind of cellular energy called adenosine triphosphate, or ATP. Some people even refer to ATP as the “energy currency of life.” ATP is a small molecule with a huge job: to provide usable energy for our cells. ATP is produced through cellular respiration, which includes the following 4 steps:

  1. Glycolysis
  2. Pyruvate oxidation
  3. Citric acid cycle (aka Kreb’s cycle)
  4. Oxidative phosphorylation

Most of this activity occurs within the mitochondria, the “powerhouse” of the cell. For the sake of this article, we’ll focus on the last step, oxidative phosphorylation. That’s where light therapy is believed to help the most.

This fourth step of cellular respiration involves an electron transport chain. As electrons move down this chain, energy is released and used to pump protons out of a matrix, forming a gradient. Protons flow back into the matrix through an enzyme called ATP synthase, which creates ATP. [6,7]

So where does ATP synthase come from? Well, a certain enzyme called cytochrome c oxidase (CCO) helps oxygen bind with nicotinamide adenine dinucleotide (NAD) + hydrogen (H)—NADH—to form the necessary hydrogen ions that produce ATP synthase.[8] If you remember anything, make sure it’s this fact: oxygen plus NADH is a good thing when it comes to healthy cellular function.

Whew! That’s some pretty meaty information. Before we go on, make sure you understand how a healthy cell is supposed to function. Take another look at the paragraphs above if you have to. And remember, oxygen plus NADH is good! 


What Happens When Our Cells Aren’t Healthy?

When we get sick, injured, stressed, etc., mitochondria in our cells can produce excess nitric oxide (NO). To understand the ramification of this, let’s go back to that little enzyme, cytochrome c oxidase.

During the creation of ATP synthase, nitric oxide competes with oxygen and binds to CCO. This, in turn, stops the eventual production of ATP and thereby increases oxidative stress, which can lead to cellular death.[9]

So in summary, stressed cells produce nitric oxide, which binds to cytochrome c oxidase and halts the production of ATP synthase.


So How Does Red Light Therapy Restore Cellular Health?

Remember, nitric oxide competes with oxygen and binds with cytochrome c oxidase, which stops the eventual production of ATP. Well, it might be best to consider red and near infrared light to be heroes when it comes to nitric oxide.

You see, red and near infrared light (with the right wavelengths and intensity) breaks the bond between nitric oxide and cytochrome c oxidase. This allows oxygen to bind to NADH, which restores the normal pathway for hydrogen ions to produce ATP synthase.[8] So in summary, red and near infrared light frees up cytochrome c oxidase to allow for the eventual production of ATP.  

By breaking that bond and restoring the production of ATP, normal cellular metabolism can resume. And once our cells are healthy again, we’ll see the following benefits that have been proven time and time again through published clinical literature:

  • Increased collagen production due to stimulated fibroblasts via the release of cytokines[1]
  • Enhanced circulation through the formation of new capillaries[3]
  • Improved anti-inflammatory emissions due to increased lymph system activity[5]
  • Increased muscle recovery, peak athletic performance, and weight loss[10]
  • Enhanced fertility[11]
  • Reduced inflammation and joint pain[4]
  • And believe it or not, a lot more!

Why Collagen is so Important for Enhanced Health

Collagen is a long-chain amino acid and the most abundant protein in the body. It’s responsible for giving skin elasticity, hair its strength, and connective tissue its ability to hold everything in place. In fact, the collagen protein makes up 30% of the total protein in the body, and 70% of the protein in the skin![12]

While collagen is beneficial to the entire body, it’s most noticeably beneficial to the skin. This is because as a person ages, the epidermis (outer layer of skin) becomes thinner and loses elasticity through a process called elastosis. As this happens, a person tends to show more signs of aging and acquires more wrinkles.

But don’t fear. Red light therapy restores healthy cellular function, stimulating the production of collagen—which is why so many people have reported about the rejuvenating benefits of light therapy![1]

Research Articles


Does it work

A general study was done on the effects of low-level light therapy (red light therapy) on the human body and more specifically the cells within.

Won-Serk Kim and R Glen Calderhead

Research Article Link

red light and the effects on our skin

A Controlled Trial to Determine the Efficacy of Red and Near-Infrared Light Treatment in Patient Satisfaction, Reduction of Fine Lines, Wrinkles, Skin Roughness, and Intradermal Collagen Density Increase

Alexander Wunsch and Karsten Matuschka

Research Article Link

Hundreds of Researched Red light Therapy Articles

US National Library of Medicine National Institutes of Health

Research Article Links


Nasa Study for cancer patient pain relief

NASA Light Technology Successfully Reduces Cancer Patients Painful Side Effects from Radiation and Chemotherapy

 Steven E. Roy 

Research Article Link

 Effects on mood and diabetes

Light therapy for better mood and insulin sensitivity in patients with major depression and type 2 diabetes: a randomized, double-blind, parallel-arm trial.

Annelies Brouwer, Daniël H. van Raalte, Michaela Diamant, Femke Rutters, Eus J.W. van Someren, Frank J. Snoek,Aartjan T.F. Beekman, and Marijke A. Bremmer

Research Article Link


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